RedIF

RedIF is formed by Ibero-American researchers working in different lines of investigation in pharmacometrics. To showcase the scientific work of research groups established in Ibero-American institutions whose coordinators are members of RedIF, we are pleased to share selected publications from 2025.

Below are representative works from research groups in Argentina, Brazil, Colombia, Spain, and Uruguay, highlighting the diverse applications of pharmacometrics across the region. One publication per research group has been selected to be featured here.

Argentina

Population pharmacokinetics and bioavailability of tacrolimus oral suspension in children with haematopoietic stem cell transplant

Brstilo L, Ibarra M, Juliá A, Testard J, Salgueiro R, Mendoza A, Pérez C, Licciardone N, Marquet P, Staciuk R, Buontempo F, Schaiquevich P.

British Journal of Clinical Pharmacology, 2025. DOI: 10.1002/bcp.70256

https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/bcp.70256

Brazil

Physiologically-based pharmacokinetic modeling and simulation for initial dose optimization of levetiracetam in pediatrics

Macente J, Bonan H, Caleffi-Marchesini ER; Pereira LRL, Lima PF, Annaert P; Karel A; Diniz A.

Frontiers in Pharmacology, v. 16, p. 1, 2025. DOI: 10.3389/fphar.2025.1678960

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1678960/full

PBPK/PD model of vancomycin in sepsis: Linking interstitial exposure in perfusion-limited tissues to MRSA infection

Ben Olivo L, Silva de Lemos JL, Jardim Rodrigues V, Batirola Kretschmer D, de Avila Cruz W, Staudt KJ, Annaert P, Verlindo de Araújo BV.

Pharmaceutics 17(9): 1111, 2025. DOI: 10.3390/pharmaceutics17091111

https://doi.org/10.3390/pharmaceutics17091111

Colombia

Novel Methods Developed in Bioequivalence Assays: Patent Review

Correa Barrera BS, Alves IA & Aragón, DM.

AAPS PharmSciTech 26: 91, 2025. DOI: 10.1208/s12249-025-03079-7

https://link.springer.com/article/10.1208/s12249-025-03079-7#citeas

Spain 

A physiologically based pharmacokinetic model to describe [89Zr]Zr-DFO-Adalimumab specific activity after intravitreal administration to rats with endotoxin-induced uveitis

Reig-López, J, García-Otero X, Cuquerella-Gilabert M, Bandín-Vilar E, Otero-Espinar FJ, Fernández-Ferreiro A, Mangas-Sanjuán V, Merino V, Aguiar P, Merino-Sanjuán M. 

International Journal of Pharmaceutics 20: 125845, 2025. DOI: 10.1016/j.ijpharm.2025.125845

https://www.sciencedirect.com/science/article/pii/S0378517325006829?via%3Dihub

Design Optimization for Developing Population Pharmacokinetic Models in Critically Ill Children: Application to Teicoplanin, Piperacillin and Meropenem

García-Orueta G, Butragueño-Laiseca L, Santiago MJ, Parra-Guillén ZP, Trocóniz IF.

Clinical Pharmacokinetics, Nov 2025. DOI: 10.1007/s40262-025-01594-1.

https://link.springer.com/article/10.1007/s40262-025-01594-1

Uruguay

Simplificación de la posología de dolutegravir en coinfección VIH/TB tratada con rifampicina: análisis mediante modelado farmacocinético de base fisiológica

Chavarría-Rojas M, Leal A, Álvarez L, Cabrera S & Ibarra M.

Revista Colombiana de Ciencias Químico-Farmacéuticas, 54(2): 509–528, 2025. DOI: 10.15446/rcciquifa.v54n2.118462

https://revistas.unal.edu.co/index.php/rccquifa/article/view/118462

Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs

Alvariza S, Ibarra M, Guevara N, Maldonado C, Vázquez M, Feijoó G, Suárez G. Frontiers in Veterinary Science 12: 1644003, 2025. DOI: 10.3389/fvets.2025.1644003.

https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1644003/full


If your RedIF research group has published work in pharmacometrics in 2025 that is not listed here, please contact us through the website’s contact form to have it included.